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B-52 gives the plant a massive energy boost by increasing its metabolism. It also increases nutrient uptake by providing naturally occurring hormones and vitamins that the plant would not get anywhere else.
No matter what growing medium is used, whether in soil or hydroponically, B-52 always works. Whether added to the nutrient tank, poured directly as a foliar spray, or dissolved in water, B-52 can and should be used throughout the plant's life, from seedling or cutting to harvest.